Colorectal Cancer Screening and Management (CRCSM) Clinical Decision Support (CDS) Implementation Guide
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: Increased Risk Exclusions - XML Representation

Draft as of 2025-02-28

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<PlanDefinition xmlns="http://hl7.org/fhir">
  <id value="flow-IncreasedRiskExclusions"/>
  <meta>
    <profile
             value="http://hl7.org/fhir/uv/cpg/StructureDefinition/cpg-computableplandefinition"/>
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<div>
    <table class="grid dict">
        
        <tr>
            <th scope="row"><b>Id: </b></th>
            <td style="padding-left: 4px;">flow-IncreasedRiskExclusions</td>
        </tr>
        

        
        <tr>
            <th scope="row"><b>Url: </b></th>
            <td style="padding-left: 4px;"><a href="PlanDefinition-flow-IncreasedRiskExclusions.html">Increased Risk Exclusions</a></td>
        </tr>
        

        
        <tr>
            <th scope="row"><b>Version: </b></th>
            <td style="padding-left: 4px;">0.1.0</td>
        </tr>
        

        

        
        <tr>
            <th scope="row"><b>Title: </b></th>
            <td style="padding-left: 4px;">Increased Risk Exclusions</td>
        </tr>
        

        

        
        <tr>
            <th scope="row"><b>Status: </b></th>
            <td style="padding-left: 4px;">draft</td>
        </tr>
        

        
        <tr>
            <th scope="row"><b>Experimental: </b></th>
            <td style="padding-left: 4px;">true</td>
        </tr>
        

        
        <tr>
            <th scope="row"><b>Type: </b></th>
            <td style="padding-left: 4px;">
                
                    
                        
                        <p style="margin-bottom: 5px;">
                            <b>system: </b> <span><a href="http://terminology.hl7.org/6.2.0/CodeSystem-plan-definition-type.html">http://terminology.hl7.org/CodeSystem/plan-definition-type</a></span>
                        </p>
                        
                        
                        <p style="margin-bottom: 5px;">
                            <b>code: </b> <span>eca-rule</span>
                        </p>
                        
                        
                    
                
                
            </td>
        </tr>
        

        

        
        <tr>
            <th scope="row"><b>Date: </b></th>
            <td style="padding-left: 4px;">2025-02-28</td>
        </tr>
        

        
        <tr>
            <th scope="row"><b>Publisher: </b></th>
            <td style="padding-left: 4px;">MITRE</td>
        </tr>
        

        
        <tr>
            <th scope="row"><b>Description: </b></th>
            <td style="padding-left: 4px;"><div><p>Determines whether a patient should be considered for average risk colorectal cancer screening or increased risk screening or surveillance. Patients who meet criteria for higher than average risk for colorectal cancer, as defined in the U.S. Preventative Services Task Force (USPSTF), are excluded from average risk screening recommendations.</p>
<p>This path can be used to ensure that USPSTF average-risk recommendations are suppressed for patients meeting increased risk criteria. It can also be used to identify and surface risk factors for colorectal cancer, and to direct patients to appropriate screening/surveillance recommendations for increased risk populations.</p>
</div></td>
        </tr>
        

        
        <tr>
            <th scope="row"><b>Knowledge Capability: </b></th>
            <td style="padding-left: 4px;">
                
                executable 
            </td>
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        <tr>
            <th scope="row"><b>Knowledge Representation Level: </b></th>
            <td style="padding-left: 4px;">
                
                structured
            </td>
        </tr>
        

        

        

        

        

        

        
        <tr>
            <th scope="row"><b>Copyright: </b></th>
            <td style="padding-left: 4px;"><div><p>(C) 2025 The MITRE Corporation. All Rights Reserved. Approved for Public Release: 24-2711. Distribution Unlimited. Unless otherwise noted, this work is available under an Apache 2.0 license. It was produced by the MITRE Corporation for the Division of Cancer Prevention and Control, Centers for Disease Control and Prevention in accordance with the Statement of Work, contract number 75FCMC18D0047, task order number 75D30123F17931.</p>
</div></td>
        </tr>
        

        
        <tr>
            <th scope="row"><b>Approval Date: </b></th>
            <td style="padding-left: 4px;">2025-02-28</td>
        </tr>
        

        

        

        
        <tr>
            <th scope="row"><b>Libraries: </b></th>
            <td style="padding-left: 4px;">
                <table class="grid-dict">
                    
                    <tr>
                        <td><code>Library/IncreasedRiskExclusions|1.0.0</code></td>
                    </tr>
                    
                </table>
            </td>
        </tr>
        

        
        <tr>
            <th scope="row"><b>Actions: </b></th>
            <td style="padding-left: 4px;">
                <table class="grid-dict">
                    
                    <tr>
                        <td>
                            
                            <b> Colorectal cancer surveillance per specialist recommendations:</b> Refer to GI specialist for colorectal cancer (and possibly additional cancers) surveillance recommendations.

Patients with a hereditary cancer syndrome require specialized management and colonoscopy surveillance for colorectal cancer (as well as additional surveillance for other cancers). Recommendations on when to start surveillance and surveillance intervals vary according to the syndrome.
                            
                            <br/>
                            
                            
                            <b>If:</b>
                            
                            <i>Applicability:</i>
                            
                            <i>(ExistsHereditarySyndrome)</i>
                            <br/>
                            
                            
                            
                            
                            <b>Then:</b> <i>Definition:</i> <code>http://cancerscreeningcds.github.io/crcsm-cds/ActivityDefinition/ColorectalCancerScreeningServiceRequest|1.0.0</code><br/>
                            
                            <i>Dynamic Values:</i><br/>
                            
                            code.coding[0]: <i>(HereditarySyndromeCode)</i>
                            <br/>
                            
                            reasonCode[0].coding[0]: <i>(HereditarySyndromeReason)</i>
                            <br/>
                            
                            
                            
                            
                        </td>
                    </tr>
                    
                    <tr>
                        <td>
                            
                            <b> IBD surveillance per specialist recommendations:</b> Start colonoscopy surveillance 8-10 years after disease onset.

Repeat colonoscopy every 1-5 years based on GI specialist recommendations.
                            
                            <br/>
                            
                            
                            <b>If:</b>
                            
                            <i>Applicability:</i>
                            
                            <i>(ExistsIBD)</i>
                            <br/>
                            
                            
                            
                            
                            <b>Then:</b> <i>Definition:</i> <code>http://cancerscreeningcds.github.io/crcsm-cds/ActivityDefinition/ColorectalCancerScreeningServiceRequest|1.0.0</code><br/>
                            
                            <i>Dynamic Values:</i><br/>
                            
                            code.coding[0]: <i>(IBDCode)</i>
                            <br/>
                            
                            reasonCode[0].coding[0]: <i>(IBDReason)</i>
                            <br/>
                            
                            
                            
                            
                        </td>
                    </tr>
                    
                    <tr>
                        <td>
                            
                            <b> Post-colorectal cancer resection surveillance:</b> Patients with a history of colorectal cancer should begin colonoscopy surveillance 1 year pos-resection.

Repeat colonoscopy 3 years after 1st surveillance, and every 5 years thereafter. Post-polypectomy surveillance intervals apply if shorter.

Refer to patient's oncologic treatment team of survivorship care plan for patient-specific guidance.
                            
                            <br/>
                            
                            
                            <b>If:</b>
                            
                            <i>Applicability:</i>
                            
                            <i>(ExistsHxCRC)</i>
                            <br/>
                            
                            
                            
                            
                            <b>Then:</b> <i>Definition:</i> <code>http://cancerscreeningcds.github.io/crcsm-cds/ActivityDefinition/ColorectalCancerScreeningServiceRequest|1.0.0</code><br/>
                            
                            <i>Dynamic Values:</i><br/>
                            
                            code.coding[0]: <i>(HxCRCCode)</i>
                            <br/>
                            
                            reasonCode[0].coding[0]: <i>(HxCRCReason)</i>
                            <br/>
                            
                            
                            
                            
                        </td>
                    </tr>
                    
                    <tr>
                        <td>
                            
                            <b> Family history increased risk screening/surveillance:</b> For patients with a single first-degree relative (mother, father, full sibling, child) with colorectal cancer or an advanced polyp(s):
* If relative diagnosed at &gt;= 60 years:
    * Start screening at 40 years old. Tests and intervals are as per average risk screening recommendations.
* If relative diagnosed at &lt; 60 years old:
    * Start screening 10 years before relative's age at diagnosis or age 40, whichever is earlier. Repeat colonoscopy every 5 years.
    * If no significant neoplasia appears by age 60 years, can offer expanding the interval between colonoscopies.

For patients with 2 or more first-degree relatives with colorectal cancer or an advanced polyp:
* Start screening colonoscopy 10 years before the reatives' youngest age at diagnosis or age 40, whichever is earlier. Repeat colonoscopy every 5 years.

Patients with a history of potentially precancerous polyps should follow shortest interval between recommendations above and recommendations based on colonoscopy findings.
                            
                            <br/>
                            
                            
                            <b>If:</b>
                            
                            <i>Applicability:</i>
                            
                            <i>(ExistsFamilyHx)</i>
                            <br/>
                            
                            
                            
                            
                            <b>Then:</b> <i>Definition:</i> <code>http://cancerscreeningcds.github.io/crcsm-cds/ActivityDefinition/ColorectalCancerScreeningServiceRequest|1.0.0</code><br/>
                            
                            <i>Dynamic Values:</i><br/>
                            
                            code.coding[0]: <i>(FamilyHxCode)</i>
                            <br/>
                            
                            reasonCode[0].coding[0]: <i>(FamilyHxReason)</i>
                            <br/>
                            
                            
                            
                            
                        </td>
                    </tr>
                    
                    <tr>
                        <td>
                            
                            <b> Post-polypectomy surveillance:</b> Follow endoscopist-recommended interval. 
                            
                            <br/>
                            
                            
                            <b>If:</b>
                            
                            <i>Applicability:</i>
                            
                            <i>(ExistsHxPolyps)</i>
                            <br/>
                            
                            
                            
                            
                            <b>Then:</b> <i>Definition:</i> <code>http://cancerscreeningcds.github.io/crcsm-cds/ActivityDefinition/ColorectalCancerScreeningServiceRequest|1.0.0</code><br/>
                            
                            <i>Dynamic Values:</i><br/>
                            
                            code.coding[0]: <i>(HxPolypsCode)</i>
                            <br/>
                            
                            reasonCode[0].coding[0]: <i>(HxPolypsReason)</i>
                            <br/>
                            
                            
                            
                            
                        </td>
                    </tr>
                    
                </table>
            </td>
        </tr>
        
    </table>
</div>
</div>
  </text>
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    <valueCode value="executable"/>
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  <extension
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  <url
       value="http://cancerscreeningcds.github.io/crcsm-cds/PlanDefinition/flow-IncreasedRiskExclusions"/>
  <version value="0.1.0"/>
  <name value="flow-IncreasedRiskExclusions"/>
  <title value="Increased Risk Exclusions"/>
  <type>
    <coding>
      <system
              value="http://terminology.hl7.org/CodeSystem/plan-definition-type"/>
      <code value="eca-rule"/>
    </coding>
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  <status value="draft"/>
  <experimental value="true"/>
  <date value="2025-02-28"/>
  <publisher value="MITRE"/>
  <contact>
    <name value="MITRE"/>
    <telecom>
      <system value="url"/>
      <value value="https://www.mitre.org/"/>
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  <description
               value="Determines whether a patient should be considered for average risk colorectal cancer screening or increased risk screening or surveillance. Patients who meet criteria for higher than average risk for colorectal cancer, as defined in the U.S. Preventative Services Task Force (USPSTF), are excluded from average risk screening recommendations.

This path can be used to ensure that USPSTF average-risk recommendations are suppressed for patients meeting increased risk criteria. It can also be used to identify and surface risk factors for colorectal cancer, and to direct patients to appropriate screening/surveillance recommendations for increased risk populations."/>
  <copyright
             value="(C) 2025 The MITRE Corporation. All Rights Reserved. Approved for Public Release: 24-2711. Distribution Unlimited. Unless otherwise noted, this work is available under an Apache 2.0 license. It was produced by the MITRE Corporation for the Division of Cancer Prevention and Control, Centers for Disease Control and Prevention in accordance with the Statement of Work, contract number 75FCMC18D0047, task order number 75D30123F17931."/>
  <approvalDate value="2025-02-28"/>
  <lastReviewDate value="2025-02-28"/>
  <author>
    <name
          value="The Health FFRDC, operated by The MITRE Corporation, in support of the Division of Cancer Prevention and Control, Centers for Disease Control and Prevention."/>
  </author>
  <editor>
    <name
          value="Division of Cancer Prevention and Control, Centers for Disease Control and Prevention"/>
  </editor>
  <reviewer>
    <name
          value="Division of Cancer Prevention and Control, Centers for Disease Control and Prevention"/>
  </reviewer>
  <endorser>
    <name
          value="Division of Cancer Prevention and Control, Centers for Disease Control and Prevention"/>
  </endorser>
  <library value="Library/IncreasedRiskExclusions|1.0.0"/>
  <action id="HereditarySyndromesSurveillance">
    <title
           value="Colorectal cancer surveillance per specialist recommendations"/>
    <description
                 value="Refer to GI specialist for colorectal cancer (and possibly additional cancers) surveillance recommendations.

Patients with a hereditary cancer syndrome require specialized management and colonoscopy surveillance for colorectal cancer (as well as additional surveillance for other cancers). Recommendations on when to start surveillance and surveillance intervals vary according to the syndrome."/>
    <documentation>
      <type value="citation"/>
      <label value="ACG Hereditary Syndromes (2015)"/>
      <display
               value="ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes"/>
      <citation
                value="Syngal, S., et al. (2015). ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes. American Journal of Gastroenterology 110(2):p 223-262. https://doi.org/10.1038/ajg.2014.435"/>
    </documentation>
    <condition>
      <kind value="applicability"/>
      <expression>
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        <expression value="ExistsHereditarySyndrome"/>
      </expression>
    </condition>
    <definitionCanonical
                         value="http://cancerscreeningcds.github.io/crcsm-cds/ActivityDefinition/ColorectalCancerScreeningServiceRequest|1.0.0"/>
    <dynamicValue>
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    </dynamicValue>
  </action>
  <action id="IBDIncreasedRisk">
    <title value="IBD surveillance per specialist recommendations"/>
    <description
                 value="Start colonoscopy surveillance 8-10 years after disease onset.

Repeat colonoscopy every 1-5 years based on GI specialist recommendations."/>
    <documentation>
      <type value="citation"/>
      <label value="ACG Crohn's Disease (2018)"/>
      <display
               value="ACG Clinical Guideline: Management of Crohn's Disease in Adults"/>
      <citation
                value="Lichtenstein, G.R., et al. (2018). ACG Clinical Guideline: Management of Crohn's Disease in Adults. American Journal of Gastroenterology, 113(4), 481-517. https://doi.org/10.1038/ajg.2018.27"/>
    </documentation>
    <documentation>
      <type value="citation"/>
      <label value="ACG Ulcerative Colitis (2019)"/>
      <display value="ACG Clinical Guideline: Ulcerative Colitis in Adults"/>
      <citation
                value="Rubin, D. T., et al. (2019). ACG Clinical Guideline: Ulcerative Colitis in Adults. The American journal of gastroenterology, 114(3), 384-413. https://doi.org/10.14309/ajg.0000000000000152"/>
    </documentation>
    <documentation>
      <type value="citation"/>
      <label value="AGA Inflammatory Bowel Disease (2021)"/>
      <display
               value="AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review"/>
      <citation
                value="Murthy, S. K., et al. (2021). AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review. Gastroenterology, 161(3), 1043-1051.e4. https://doi.org/10.1053/j.gastro.2021.05.063"/>
    </documentation>
    <condition>
      <kind value="applicability"/>
      <expression>
        <language value="text/cql-identifier"/>
        <expression value="ExistsIBD"/>
      </expression>
    </condition>
    <definitionCanonical
                         value="http://cancerscreeningcds.github.io/crcsm-cds/ActivityDefinition/ColorectalCancerScreeningServiceRequest|1.0.0"/>
    <dynamicValue>
      <path value="code.coding[0]"/>
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      <expression>
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        <expression value="IBDReason"/>
      </expression>
    </dynamicValue>
  </action>
  <action id="HistoryCRCSurveillance">
    <title value="Post-colorectal cancer resection surveillance"/>
    <description
                 value="Patients with a history of colorectal cancer should begin colonoscopy surveillance 1 year pos-resection.

Repeat colonoscopy 3 years after 1st surveillance, and every 5 years thereafter. Post-polypectomy surveillance intervals apply if shorter.

Refer to patient's oncologic treatment team of survivorship care plan for patient-specific guidance."/>
    <documentation>
      <type value="citation"/>
      <label value="USMSTF Post Colorectal Cancer Resection (2016)"/>
      <display
               value="Colonoscopy Surveillance after Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer"/>
      <citation
                value="Kahi, C. J., et al. (2016). Colonoscopy Surveillance after Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology, 150(3), 758-768.e11. https://doi.org/10.1053/j.gastro.2016.01.001"/>
    </documentation>
    <documentation>
      <type value="citation"/>
      <label
             value="USMSTF Follow-Up After Colonoscopy and Polypectomy (2020)"/>
      <display
               value="Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer"/>
      <citation
                value="Gupta, S., et al. (2020). Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology, 158(4), 1131–1153.e5. https://doi.org/10.1053/j.gastro.2019.10.026"/>
    </documentation>
    <condition>
      <kind value="applicability"/>
      <expression>
        <language value="text/cql-identifier"/>
        <expression value="ExistsHxCRC"/>
      </expression>
    </condition>
    <definitionCanonical
                         value="http://cancerscreeningcds.github.io/crcsm-cds/ActivityDefinition/ColorectalCancerScreeningServiceRequest|1.0.0"/>
    <dynamicValue>
      <path value="code.coding[0]"/>
      <expression>
        <language value="text/cql-identifier"/>
        <expression value="HxCRCCode"/>
      </expression>
    </dynamicValue>
    <dynamicValue>
      <path value="reasonCode[0].coding[0]"/>
      <expression>
        <language value="text/cql-identifier"/>
        <expression value="HxCRCReason"/>
      </expression>
    </dynamicValue>
  </action>
  <action id="FamilyHistoryIncreasedRisk">
    <title value="Family history increased risk screening/surveillance"/>
    <description
                 value="For patients with a single first-degree relative (mother, father, full sibling, child) with colorectal cancer or an advanced polyp(s):
* If relative diagnosed at &gt;= 60 years:
    * Start screening at 40 years old. Tests and intervals are as per average risk screening recommendations.
* If relative diagnosed at &lt; 60 years old:
    * Start screening 10 years before relative's age at diagnosis or age 40, whichever is earlier. Repeat colonoscopy every 5 years.
    * If no significant neoplasia appears by age 60 years, can offer expanding the interval between colonoscopies.

For patients with 2 or more first-degree relatives with colorectal cancer or an advanced polyp:
* Start screening colonoscopy 10 years before the reatives' youngest age at diagnosis or age 40, whichever is earlier. Repeat colonoscopy every 5 years.

Patients with a history of potentially precancerous polyps should follow shortest interval between recommendations above and recommendations based on colonoscopy findings."/>
    <documentation>
      <type value="citation"/>
      <label value="USMSTF (2017)"/>
      <display
               value="Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer"/>
      <citation
                value="Rex, D. K., et al. (2017). Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer. Gastroenterology, 153(1), 307-323. https://doi.org/10.1053/j.gastro.2017.05.013"/>
    </documentation>
    <documentation>
      <type value="citation"/>
      <label value="ACG Average Risk (2021)"/>
      <display
               value="ACG Clinical Guidelines: Colorectal Cancer Screening 2021"/>
      <citation
                value="Shaukat, A., et al. (2021). ACG Clinical Guidelines: Colorectal Cancer Screening 2021. American Journal of Gastroenterology, 116(3), 458-479. https://doi.org/10.14309/ajg.0000000000001122"/>
    </documentation>
    <documentation>
      <type value="citation"/>
      <label
             value="USMSTF Follow-Up After Colonoscopy and Polypectomy (2020)"/>
      <display
               value="Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer"/>
      <citation
                value="Gupta, S., et al. (2020). Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology, 158(4), 1131–1153.e5. https://doi.org/10.1053/j.gastro.2019.10.026"/>
    </documentation>
    <condition>
      <kind value="applicability"/>
      <expression>
        <language value="text/cql-identifier"/>
        <expression value="ExistsFamilyHx"/>
      </expression>
    </condition>
    <definitionCanonical
                         value="http://cancerscreeningcds.github.io/crcsm-cds/ActivityDefinition/ColorectalCancerScreeningServiceRequest|1.0.0"/>
    <dynamicValue>
      <path value="code.coding[0]"/>
      <expression>
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        <expression value="FamilyHxCode"/>
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    <dynamicValue>
      <path value="reasonCode[0].coding[0]"/>
      <expression>
        <language value="text/cql-identifier"/>
        <expression value="FamilyHxReason"/>
      </expression>
    </dynamicValue>
  </action>
  <action id="HistoryPolypsIncreasedRisk">
    <title value="Post-polypectomy surveillance"/>
    <description value="Follow endoscopist-recommended interval. "/>
    <documentation>
      <type value="citation"/>
      <label
             value="USMSTF Follow-Up After Colonoscopy and Polypectomy (2020)"/>
      <display
               value="Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer"/>
      <citation
                value="Gupta, S., et al. (2020). Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology, 158(4), 1131–1153.e5. https://doi.org/10.1053/j.gastro.2019.10.026"/>
    </documentation>
    <condition>
      <kind value="applicability"/>
      <expression>
        <language value="text/cql-identifier"/>
        <expression value="ExistsHxPolyps"/>
      </expression>
    </condition>
    <definitionCanonical
                         value="http://cancerscreeningcds.github.io/crcsm-cds/ActivityDefinition/ColorectalCancerScreeningServiceRequest|1.0.0"/>
    <dynamicValue>
      <path value="code.coding[0]"/>
      <expression>
        <language value="text/cql-identifier"/>
        <expression value="HxPolypsCode"/>
      </expression>
    </dynamicValue>
    <dynamicValue>
      <path value="reasonCode[0].coding[0]"/>
      <expression>
        <language value="text/cql-identifier"/>
        <expression value="HxPolypsReason"/>
      </expression>
    </dynamicValue>
  </action>
</PlanDefinition>