Description

Patient population that have been identified as higher than average risk or otherwise requiring specific consideration within a particular guideline. Provides criteria to determine age to start, screening modality, and screening interval for these populations of patients.

Mid-Level Flow

Patient population Age group Source Recommendation
Lifetime risk of breast cancer > 20% or 25% <30 ACS Start screening at 30 years old
Lifetime risk of breast cancer > 20% or 25% <30 USPSTF Start screening at 40 years old
Lifetime risk of breast cancer > 20% or 25% 30-39 ACS Annual screening mammogram
Annual screening MRI
Lifetime risk of breast cancer > 20% or 25% 30-39 USPSTF Start screening at 40 years old
Lifetime risk of breast cancer > 20% or 25% >=40 ACS Annual screening mammogram
Annual screening MRI
Lifetime risk of breast cancer > 20% or 25% >=40 USPSTF Biennial screening mammogram
First degree relative with genetic marker or syndrome <30 ACS Start screening at 30 years old
First degree relative with genetic marker or syndrome <30 USPSTF Start screening at 40 years old
First degree relative with genetic marker or syndrome 30-39 ACS Annual screening mammogram
Annual screening MRI
First degree relative with genetic marker or syndrome 30-39 USPSTF Start screening at 40 years old
First degree relative with genetic marker or syndrome >=40 ACS Annual screening mammogram
Annual screening MRI
First degree relative with genetic marker or syndrome >=40 USPSTF Biennial screening mammogram
BI-RADS breast density category C or D? <40 ACS Perform lifetime risk assessment
BI-RADS breast density category C or D? <40 USPSTF Start screening at 40 years old
BI-RADS breast density category C or D? >=40 ACS Perform lifetime risk assessment
BI-RADS breast density category C or D? >=40 USPSTF Biennial screening mammogram
Compelling family history of breast cancer <40 ACS Perform lifetime risk assessment
Compelling family history of breast cancer <40 USPSTF Start screening at 40 years old
Compelling family history of breast cancer >=40 ACS Perform lifetime risk assessment
Compelling family history of breast cancer >=40 USPSTF Biennial screening mammogram

Semi-Structured Logic Statements

Inclusions

None.

Exclusions

None.

Events

NameDescription
Patient population
Population to which the patient fits criteria
Age group
Patient age group
Source
Source of recommendation
Lifetime risk of breast cancer > 20% or 25%
First degree relative with genetic marker or syndrome
BI-RADS breast density category C or D?
Compelling family history of breast cancer
Pedigree of blood relatives on both maternal and paternal side includes compelling history of breast cancer.
'Compelling family history of breast cancer' is true
<30
Patient age < 30 years
30-39
Patient age >= 30 and <=39
>=40
Patient age >=40
<40
Patient age < 40 years
ACS
Source of recommendation is ACS
USPSTF
Source of recommendation is USPSTF
NCCN
Source of recommendation is NCCN

Actions

Start screening at 30 years old
Description
Source: ACS
Pseudocode
Next due date = date patient is 30 years old
Start screening at 40 years old
Description
Source: USPSTF
Pseudocode
Next due date = date patient is 40 years old
Annual screening mammogram
Description
Source: ACS
Women who are at high risk for breast cancer based on certain factors should get a breast MRI and a mammogram every year, typically starting at age 30.
Pseudocode
Screening age = >= 30
Screening modality = mammography
Screening interval = annual
Next due date = 'Date of last mammography' plus 1 year OR Now if 'Last mammography' does not exist
Annual screening MRI
Description
Source: ACS
Women who are at high risk for breast cancer based on certain factors should get a breast MRI and a mammogram every year, typically starting at age 30.
Pseudocode
Screening age = >= 30
Screening modality = MRI
Screening interval = annual
Next due date = 'Date of last MRI' plus 1 year OR Now if 'Last MRI' does not exist
Annual screening mammogram only
Description
Source: ACS
Women who are at high risk for breast cancer based on certain factors should get a mammogram every year, typically starting at age 30. There’s not enough evidence to make a recommendation for or against yearly MRI screening for women who have a higher lifetime risk based on certain factors.
Pseudocode
Screening age = >= 30
Screening modality = mammography
Screening interval = annual
Next due date = 'Date of last mammography' plus 1 year OR Now if 'Last mammography' does not exist
Biennial screening mammogram
Description
Source: USPSTF
Pseudocode
Screening age = >= 40
Screening modality = mammography
Screening interval = biennial
Next due date = 'Date of last mammography' plus 2 years OR Now if 'Last mammography' does not exist
Perform lifetime risk assessment
Description
Perform assessment of lifetime risk, as defined by models largely dependent on family history. Result of risk assessment informs next step, either proceed to recommendations for Lifetime risk of breast cancer > 20% or 25% or else patient does not meet criteria for special populations.

Validated tools include BRCAPRO, Claus, BOADICEA [Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm], and Tyrer-Cuzick.

Source: ACS
Pseudocode
Perform assessment of lifetime risk, as defined by models largely dependent on family history.

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Public Release Case Number 24-2711
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