Description

This logic path provides colorectal cancer screening recommendations for individuals with inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis.

Mid-Level Flow Diagram

Primary SclerosingCholangitis?Indeterminate ormicroscopic colitis?Recommendation: initialcolonoscopy at PSC diagnosis andsurveillance colonoscopy every yearPatients not at increased risk forcolorectal cancerRecommendation: Initialcolonoscopy 8-10 years afterdisease onset and surveillancecolonoscopy every 1-5 yearsyesnoyesno

Semi-Structured Logic Statements

Inclusions

NameDescription
Patients with a personal history of inflammatory bowel disease
Patients with a personal history of inflammatory bowel disease (ulcerative colitis or Crohn's disease)

Exclusions

None.

Events

NameDescription
Primary Sclerosing Cholangitis?
CONDITIONS include `Primary Sclerosing Cholangitis`
Indeterminate or microscopic colitis?
CONDITIONS include `Indeterminate Colitis` with status active
OR
CONDITIONS include `Microscopic Colitis` with status active

Actions

Recommendation: initial colonoscopy at PSC diagnosis and surveillance colonoscopy every year
Description
RECOMMENDATION:
* Initial screening colonoscopy: at the time of PSC diagnosis.
* Surveillance interval: colonoscopy every year.

Source: AGA, 2021; ACG, 2015; ACG, 2018; ACG, 2019
Pseudocode
Patients not at increased risk for colorectal cancer
Description
Patients with microscopic or indeterminate colitis are not at increased risk for colorectal cancer.
Pseudocode
Recommendation: Initial colonoscopy 8-10 years after disease onset and surveillance colonoscopy every 1-5 years
Description
RECOMMENDATION:
* Initial screening colonoscopy: 8-10 years after disease onset.
* Modality and interval: colonoscopy every 1-5 years based on a recommendation from GI specialist.

Considerations:
* These recommendations do not apply to patients with Crohn's disease without colonic involvement.

Source: AGA, 2021; ASGE, 2015; ACG, 2019; ACG, 2018
Pseudocode

References

  • AGA (2021): Murthy, S. K., et al. (2021). AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review. Gastroenterology, 161(3), 1043-1051.e4. https://doi.org/10.1053/j.gastro.2021.05.063
  • ACG (2015): Lindor, K. D., et al. (2015). ACG Clinical Guideline: Primary Sclerosing Cholangitis. American Journal of Gastroenterology, 110(5), 646-659. https://doi.org/10.1038/ajg.2015.112
  • ACG (2018): Lichtenstein, G.R., et al. (2018). ACG Clinical Guideline: Management of Crohn’s Disease in Adults. American Journal of Gastroenterology, 113(4), 481-517. https://doi.org/10.1038/ajg.2018.27
  • ACG (2019): Rubin, D. T., et al. (2019). ACG Clinical Guideline: Ulcerative Colitis in Adults. The American journal of gastroenterology, 114(3), 384–413. https://doi.org/10.14309/ajg.0000000000000152
  • ASGE (2015): Shergill, A.K., et al. (2015). The role of endoscopy in inflammatory bowel disease, Gastrointestinal Endoscopy, 81(5), 1101-1121.e13. https://doi.org/10.1016/j.gie.2014.10.030

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